The legendary documentary maker will investigate the challenges facing African wildlife from issues such as climate change and deforestation and man-made problems such as poaching and encroachment on natural habitats.
Elephants and rhinos are closely examined by the show and in particular, Attenborough comes face to face with one young rhino called Elvis, who has had his horn removed to protect him from poachers.
On average two rhinos are killed a day in Africa and conservationists are attempting to protect one of the last living groups, who are currently gathered in the Kalahari.
The show will also follow a team of scientists, who are looking into whether Gorongosa National Park can become a haven for wild animals in Mozambique again, following the damage caused by civil war.
There is also footage of the Maasai warriors, who have become lion guardians.
Attenborough's latest series has been another ratings success for the natural history presenter, debuting with over 8 million viewers for episode one.
Memorable moments from the series have included the sight of giraffes at battle with a 'necking' fight and the first footage of rhinos social activity using remote starlight cameras.
The final episode of Attenborough's Africa airs on Wednesday (February 6) on BBC One at 9pm.
The TV star is hosting a Twitter session about the show tomorrow and fans can send questions to @bbcnature or @bbcone using the hashtag #AskAttenborough. He will be taking questions live on Twitter from 1pm.