The BBC One quiz, hosted by Alexander Armstrong and Richard Osman, pulled in 3.53m (22%) on Friday evening between 5.15pm and 6pm.
Bradley Walsh's The Chase, meanwhile, averaged 3.41m (22.2%) across the entire 5pm hour - still an impressive figure which consolidates its place as the broadcaster's biggest teatime show since Paul O'Grady.
The BBC's axing of afternoon children's programmes on its flagship channel has meant that Pointless inherits stronger audiences now.
Elsewhere on Friday (February 8), Great Night Out - ITV's struggling weeknight comedy drama set in Stockport - rose to 3.23m (14.1%) in the 9pm hour as well as 193k on +1.
While recording its best figure since it kicked off in mid-January, Friday's audience is still below ITV's slot average, meaning the show is unlikely to be rewarded a second run.
BBC One's Silent Witness comfortably won the hour but Great Night Out might have dented the drama as it slumped to a low of 4.87m (21.4%).
Of the other terrestrial channels' best-rated programming, Mastermind interested 2.3m (9.8%) on BBC Two, 1.39m (6.1%) watched a shortened 8 Out of 10 Cats on Channel 4 (+1: 194k), and Ice Road Truckers logged 1.01m (4.3%) on 5 (+1: 152k).
Overall, ITV pipped BBC One to another primetime victory with 21.5% (+1: 0.5%) over BBC One's 21.3%.
BBC Four's LP week came to a head with 797k (3.7%) for documentary When Albums Ruled the World, which ranked as the most-watched multichannel broadcast of the day.
BARB ratings data supplied by Attentional