It will be the first time the classic TV show has aired in the UK for nearly 17 years. It joins CBS Drama's current lineup of classic Americans soaps, which includes original series of Dallas, Melrose Place and Dynasty.
The Dallas spin-off was a big ratings hit in the '80s for CBS in America. It originally aired in the UK on the BBC.
Chris Sharp, chief programming officer for CBS Chello Zone channels, said: "After the amazing success of Dallas on CBS Drama, our viewers have demanded that we show Knots Landing next, bringing it back to UK television after 17 years.
"We are very enthusiastic about its launch. The series has many energetic storylines and incredible captivating cliff-hanging episodes, which we're sure will appeal to our ever-growing, loyal audience."
Set in a fictional coastal suburb in LA, Knots Landing centered on the lives of Gary and Valene Ewing and three other families - the Fairgates, the Averys and the Wards.
The cast included Nicollette Sheridan, Ted Shackelford, Joan Van Ark, Donna Mills and Michele Lee, and featured appearances from Alec Baldwin, Halle Berry and Marcia Cross.
Knots Landing will air from Monday, April 1 at 11pm on CBS Drama.