The returning Channel 4 comedy will follow JP (Jack Whitehall), Howard (Greg McHugh), Vod (Zawe Ashton), Oregon (Charlotte Ritchie) and Kingsley (Joe Thomas) as they begin their second university term.
Josie (Kimberley Nixon) is in Southampton, away from her old housemates but in contact via iPad, when the new eight-part series opens.
In her place comes a new housemate - fresher Candice, who catches JP's eye - while Vod also returns from her travels with a "new Mexican beefcake lover" named Javier.
Objective Productions' Head of Drama and co-exec producer Judy Counihan said: "Our fabulous gang of six returns to navigate their second year; no longer freshers, but eager as ever to experience uni life to the full and beyond – and there's an unsuspecting newbie to educate, too."
Roberto Troni, drama commissioning editor, added: "We're thrilled to have the Fresh Meat gang coming back to Channel 4 for a new academic year and a new series. Sam & Jesse and our brilliant cast return once again to remind us of those excruciatingly awkward yet seminal uni days, in their inimitable and hilarious style.
"The residents of Hartnell Avenue may be a year older but - thankfully - they're none the wiser, as they deal with new responsibilities, new housemates and new loves, heartbreak, heartache and few unwanted blasts from the pasts."
Filming on the new series of Fresh Meat begins next month in Manchester.
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Watch a clip from Fresh Meat below: