Thunderbirds Are Go! - first announced in February - will combine CGI animation with live-action footage.
The World's End star Pike will voice Lady Penelope, with original Thunderbirds voice artist David Graham reprising his role of her chauffeur Parker.
"I'm very excited to bring Lady Penelope's wry wit and taste for adventure to a new generation," said Pike. "Exploring the scenes with David Graham has been an absolute delight.
"The scripts are very modern, very fresh and very funny. We're all eagerly anticipating our next stint in the recording studio!"
The 88-year-old Graham added: "I am triple chuffed to be on board the new series of Thunderbirds Are Go! and reprising my role of dear old Parker with such a distinguished cast.
"My driving skills are in good nick and I am delighted to be behind the wheel again with M'Lady. Cheerio!"
Novak will voice inventor Brains, with Game of Thrones star Thomas Brodie-Sangster playing the dual role of Tracy brothers Gordon and John.
Merlin star Coulby is new character Kayo - a friend of the Tracy brothers - while master villain The Hood will be voiced by Andres Williams.
Also cast in Thunderbirds Are Go! are Rasmus Hardiker (Alan and Scott Tracy), David Menkin (Virgil Tracy) and Sandra Dickinson (Grandma Tracy).
The 26-episode series will debut on ITV and the CITV Channel in 2015.
> Thunderbirds returns: F.A.B. or a big mistake?
Watch the intro to the classic Thunderbirds below: