Hermione Norris, Tara Fitzgerald and Katherine Parkinson are also among the cast members of the six-part series from The Syndicate's Kay Mellor.
In the Club will be centred around the birth of a new baby in a modern family, following six different couples who connect at the local Parent Craft class.
Jonathan Kerrigan, Christine Bottomley, Luke Thompson, Taj Atwal, Sacha Dhawan and Hannah Midgley have also been cast.
Kay Mellor said: "I'm really excited by the calibre of cast we've attracted; the level of talent is staggering. I feel flattered and honoured to have such amazing actors bringing my characters to life."
Norris will play businesswoman Roanna, who has two adult children and finds herself pregnant again with her young artist lover Simon (Thompson).
Diana (Halfpenny) and Rick (Mellor) are expecting a 'miracle' child after being told they could never conceive. However, a scan reveals another shock, while Rick hides his own secret.
Susie (Fitzgerald) and Kim (Parkinson) are expecting their second child via the same biological father. Kim is pregnant with the child this time around, but the arrangement with Susie's ex and sperm donor Neil (Kerrigan) has unexpected consequences.
Yasmin (Atwal) and husband Dev (Dhawaan) are together through an arranged marriage, and are now expecting their 'honeymoon baby'. However, issues arise over the baby's due date.
Rosie (Midgley) is a schoolgirl who is hiding her pregnancy from everyone in her life, while midwife Vicky (Bottomley) is terrified of her own birth, especially when it comes to who the father of the baby is.
In the Club begins filming in and around Leeds in January.
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