A lifestyle and cookery programme, the series has been given 12 episodes and will launch on April 26 at 9am.
Guests confirmed to take part include top chefs Heston Blumenthal, Raymond Blanc, Michel Roux Jnr, John Torode and Angela Harnett.
Each week the chefs will cook up dishes using Waitrose's seasonal ingredients, and Jones and Snowdon will chat with celebrity guests.
Waitrose will promote the show via in-store promotions and their own publications.
Nick Bullen from producers Spun Gold said: "We're excited to embark on this new project with Waitrose, extending our relationship with the brand to produce their first ever television programme.
"We have been working with Waitrose for some time and, together with Channel 4, we have created a show which takes the Waitrose brand into a whole new arena.
"We are confident that Weekend Kitchen with Waitrose will prove to be an innovative and engaging multiplatform production for the viewer and an innovative production partnership for Spun Gold, Waitrose and Channel 4."