Osman will host new daytime series Two Tribes, which sees seven contestants being split into two teams based on what they have in common.
Before the episode, the contestants are asked hundreds of "probing, funny and surprising" questions about themselves - and each round, they will be split into two tribes depending on whether they answered yes or no.
The two teams will then face 60 seconds of general knowledge questions, with the losing tribe being forced to face the buzzer - and the last person to buzz in with a correct answer is eliminated.
New tribes are created in each round, until the final two players left in the game go head to head for a cash prize.
Executive producer James Fox described Two Tribes as a "brilliantly play-along game as you root for the tribe you belong to and answer lots of quick-fire general knowledge questions".
He added: "We're really looking forward to seeing Richard come out from behind the Pointless desk to front the show and get to know the contestants like never before."
Two Tribes will air 30 episodes on BBC Daytime later this year, while hopeful contestants can apply by emailing firstname.lastname@example.org.