Sarpong quits 'T4' after six years
She will be replaced by new host Rick Edwards who joins other young faces Steve Jones, Miquita Oliver and Alexa Chung.
Sarpong's stint at the youth show has seen her interview Tony Blair, while earlier this year she got an MBE for services to broadcasting and charity.
Her exit comes after fellow old hand Vernon Kay left.
A source commented: "June feels she’s been doing the trendy teenage stuff for long enough. She’s after something a little more serious to get her teeth into."