Simon Cowell, Sharon Osbourne and Louis Walsh will take the reins of a section of the seven-hour show and Arlene Phillips will be responsible for another.
This year's telethon is the first time guest presenters will feature alongside Terry Wogan and Fearne Cotton.
Other stars scheduled to appear include Kylie Minogue, Myleene Klass and Torchwood star John Barrowman.
Four members of the Hollyoaks cast are to perform a Marc Bolan medley, while CBBC favourites Sam and Mark will also take on some presenting duties.
Strictly contestant Brian Capron recently revealed that he is to cook at top Belfast restaurant Ginger alongside Dana and Jan Leeming on Friday to raise money.
Children In Need airs on BBC One on Friday at 7pm.