Four members of the iconic Manchester band – lead singer Shaun Ryder, percussionist Bez, drummer Gary Whelan and backing vocalist Julie Gordon – will hold a seance at a Victorian jail in Lincoln, before tracking down spectres at a Nottingham manor house that was used for sex parties in Elizabethan times.
Pop groups Girls Aloud and McFly, several members of the Emmerdale cast and a group of Radio 1 DJs have previously appeared on the show, which is hosted by former Blue Peter presenter Yvette Fielding.
Bez, the winner of Celebrity Big Brother in 2005, said: "You've got to watch this one, man - especially if you don't believe in 'em. Yvette's not kidding when she says that she doesn't know who's gonna be more scared - the ghosts or us. You decide!"
Ghost Hunting With… The Happy Mondays will air on ITV2 later this year.