The Hits takes C4's music on Sunday nights
The Channel 4 content including live shows, videos and interviews will air from 5pm-midnight between March 2 and May 4.
Among the programmes will be live performances from Take That, Justin Timberlake, Christina Aguilera and Kylie.
4Music Sundays will also include the fourth series of The Shockwaves Album Chart Show and exclusive videos and is billed as putting "the viewer at the centre of the music".
Channel 4 bought a 50% stake in Box TV, Emap's music television division, which runs The Hits, in July.
Box TV programming director Dave Young said: "4Music Sundays is our first major initiative since forming the Box TV joint venture business between Emap and Channel 4. I'm incredibly excited about the quality of programme mix we’re about to deliver."
Emap Advertising's Darren Khan added: "As advertisers look for new ways to connect with their audiences, it’s important to innovate in product and content.
"4Music Sundays will be unmissable music entertainment, and only available on the UK’s number one music channel."