Speaking to Heart FM , the 46-year-old said: "We've been asked. We sort of nearly did it a few years ago and then Caroline Quentin suddenly felt quite strongly that she didn't want to do it.
"Then they said would Neil Morrissey and I just do as the boys but that wasn't the point of the show. It was always about the four of us, so that wouldn't have worked really."
Clunes admitted he was wouldn't return to the show, saying it still had life on satellite TV.
"I don't know, maybe it's a good idea to leave these things alone. It's always on UK Gold or Dave or some satellite TV channel anyway so do we really need a new one?
"It's been ten years since we did the last episode but people still like it, I still like it. It was a very funny show. I'm very proud of it," Clunes added.
Men Behaving Badly ran for 42 episodes from 1992 to 1998.
The first series starred Harry Enfield but he was replaced by Neil Morrissey from series two onwards.
The ITV show was cancelled after two series, then quickly picked up by the BBC, where it continued until late 1998.