Asked on The Xtra Factor about the group, Aston Merrygold described it as the "start for them".
He continued: "They have to move on and go 'what's next?'"
Marvin Humes added: "Someone's got to go, every week it's difficult to pinpoint the reason why... maybe they didn't connect with people at home."
Asked if the duo have a future in the music business, Humes said: "Yeah, I think they have. They were a band before they came into the show and they obviously had that solid unit and I enjoy watching them, I'm actually gutted they left. Hopefully they'll stick it out and keep going."
JLS found themselves in the bottom two when they competed in The X Factor before going on to claim second place in 2008.
The group admitted that it is a "horrible place to be" but advised Kye Sones, who was saved ahead of MK1, to "put it behind him".
Hosts Caroline Flack and Olly Murs then pushed the 'Beat Again' group to choose their favourite act this year.
James Arthur received praise from Merrygold, Oritsé Williams and JB Gill, while Humes chose Jahmene Douglas as his favourite contestant.
Williams praised Arthur for his "passionate" and seemingly "unrehearsed" performances.
The group performed their new single 'Hottest Girl in the World' on tonight's (October 21) results show and will release their fourth album Evolution on November 5.
Watch JLS perform 'Hottest Girl in the World' on The X Factor below:
Photo gallery - The X Factor Club Classics results show:
Copyright: Ken McKay/Thames/Rex Features