They will appear on a special edition of the ITV series on Saturday, November 2 to perform three songs.
Rodgers will play his 1959 Fender Stratocaster, known as 'The Hit Maker', which has featured on tracks by Madonna, David Bowie and Diana Ross.
He has enjoyed a successful year following his collaboration with Daft Punk and Pharrell Williams on 'Get Lucky'. He has gone on to work with the likes of Avicii, Disclosure and David Guetta.
Meanwhile, Lady Gaga will give a world exclusive first performance of her new single 'Venus' on this Sunday's (October 27) results show.
Nile Rodgers Presents The Chic Organisation: Up All Night: The Greatest Hits Disco Edition will be released via Warner Music and Rhino UK on October 28.
> 5 talking points from this week's 'X Factor'
> X Factor' week two review: Love, heartache and surrealism in spades
Watch Nile Rodgers and Chic perform 'Le Freak' at Glastonbury earlier this year below: