Erin Boag, Flavia Cacace, Vincent Simone and Aliona Vilani will not take part in the 2013 series, the BBC has confirmed (via PA).
Vilani won the show in 2011 as the partner of McFly's Harry Judd but did not compete in the last series due to injury. Meanwhile, Boag, Cacace and Simone reportedly want to leave to "focus on their careers outside of Strictly and for professional reasons".
Boag partnered rugby player Martin Offiah in the first series in 2004 and leaves the show after a decade.
She said: "After 10 wonderful years, and with a truly heavy heart, I have decided to decline the BBC's very kind offer to compete again in series 11, and have withdrawn from being a competitive dancer on Strictly Come Dancing.
"It's been so much fun making new friends, meeting wonderful people, and of course being partnered with such lovely celebrities year after year. I'm going to miss spending so much time with my amazing fellow professional dancers - it's true what they say, Strictly really is just like a great big family!
"It's been a very hard decision to make, but it's time for a change and to focus my attention on new challenges. That said, it's not necessarily farewell to Strictly, as I do hope to continue being a part of the show."
Strictly Come Dancing returns to the BBC for an eleventh series this Autumn.