The 33-year-old said that the multi-millionaire would be taking a risk if he picked another male employee.
"Surely Sir Alan can't fire all the girls again?" she told The Sun. "If he does, he'll be in the s**t."
Hopkins withdrew from series three of the show at the interview stage, admitting that she was unsure that she could offer the necessary commitment to the £100,000-a-year job.
Kate Walsh, Yasmina Siadatan, Debra Barr and Lorraine Tighe are among the final five contestants on this year's show. James McQuillan is the only remaining male candidate.
Sir Alan Sugar has picked three males winners - Simon Ambrose, Tim Campbell and Lee McQueen - and one female victor, Michelle Dewberry, in the show's history.
The Apprentice continues on Wednesday at 9pm on BBC One.