The paranormal drama's latest run will feature a new lead cast, with original star Lenora Crichlow appearing alongside Michael Socha and Damien Molony.
The new video clip includes footage of new vampire Hal (Molony) and hints at emotional scenes for werewolf George (Russell Tovey).
Tovey has announced that he is to exit the series, with his former co-stars Aidan Turner and Sinead Keenan having already filmed their final scenes.
The series four preview also gives fans their first glimpse at guest star Mark Williams. The Harry Potter actor will play a character named Regus in the new run.
Sherlock's Mark Gatiss and former Teachers star James Lance have also signed up for guest roles.
Watch the new trailer for Being Human series four below: