The actress said that although Annie's story has come "to a natural end" and it "feels right" for her alter ego to have passed into the afterlife at the end of this year' series, she wouldn't be surprised if Being Human creator Toby Whithouse finds a way to bring her back.
She told DS: "I felt Annie's story came to a natural end, I felt very loved as I left the show... Of course [Annie could come back], I'm a ghost.
"Seriously, there are no rules. Toby, the writer, he can do what he wants and he does do what he wants.
"I would say yes [if asked]. It depends on what would happen. At the moment it feels right that Annie has moved on and I like to think of her in the afterlife having a really great time. So, if the timing was right, who knows?"
Asked if she will be watching Being Human when it returns for its fifth series in 2013, Crichlow replied: "Oh God, yeah. I can't wait. It will be a bit weird, but [I'm] definitely going to tune in."
Being Human star Michael Socha, who plays werewolf Tom, similarly told Digital Spy in April that Annie's fate was "never sealed".
"With Being Human, it's never the end," he said. "These people who die or leave do sometimes come back, so hopefully we'll see Lenora again."
Crichlow was speaking to promote upcoming ITV movie Doors Open, an adaptation of the Ian Rankin book of the same name also starring Stephen Fry and Douglas Henshall. The art heist thriller will air next month.