Production company Kudos has taken the decision to end the show. However, it has promised that the BBC One espionage drama will end "in its prime", with a focus on counter-terrorism chief Sir Harry Pearce (Peter Firth).
Jane Featherstone of Kudos told The Guardian: "I feel very sad about it. It was a very difficult decision to make.
"But we didn't want to get to the point where the BBC said, 'We don't really want another one', we wanted to kill it off in its prime."
Featherstone added that she feels Pearce and his colleague Ruth Evershed (Nicola Walker) are "the heart of the show". She also promised that their story would have a "natural end".
Spooks debuted in 2002 and has featured a host of well-known British actors including Matthew Macfadyen, Keeley Hawes, Hermione Norris, Richard Armitage, Sophia Myles and Rupert Penry-Jones.
Ben Stephenson, controller, BBC Drama commissioning, said in a statement: "Kudos created a groundbreaking series in Spooks ten years ago that challenged convention with its topical, fast-paced, contemporary style.
"It quickly became a hit with audiences and established itself as a key part of the BBC One schedule and redefined drama on the channel for a new generation... [I] hope fans will tune in this September to see what promises to be a fittingly high-octane, thrilling finale."
> 'Spooks' tenth series begins production
> Peter Firth: 'Spooks is better than ever'
Watch a clip from the series nine finale of Spooks below: