Derry's Diona Doherty, gap year student Louisa Warwick and Dudley's Anna Vokes were all voted off the show by Elle Macpherson and the judges.
Later, 18-year-old Amelia 'Millie' Raven walked out of the show for personal reasons.
Speaking to the girls who were voted out, Macpherson said: "I have three beautiful girls in front of me, and I really want to thank you for all the work and excitement and interest you've brought to the competition thus far.
"And I wish you well and this is just the end of the journey for this time. So whatever you choose to do, I wish you luck and I thank you."
Anna claimed that she wouldn't be deterred by the setback, commenting: "Obviously I'm gutted that I'm not going to be in the house, but some girls I know really, really want it have got in, so I'm really, really happy for them and I want them to win it for me now.
"I'm going to come back next year fighting harder and stronger, 'cos that's how I roll. You can never keep me down."
Britain & Ireland's Next Top Model continues on Mondays at 9pm on Sky Living.