The Biggest Loser previously aired on Living for two series in 2005 and 2006, before moving to ITV daytime last year. Last year's run, which was hosted by GMTV's Kate Garraway, was won by Kevin Sage, who lost 9 stone 6lbs.
The fourth series will run for eight hour-long episodes, which will air in early 2011. It is not confirmed whether Garraway will return as the host.
Joint managing director Karen Smith from production company Shine TV said: "Despite its cheeky title, The Biggest Loser is a hugely positive series which genuinely transforms people's lives for the better.
"Last year’s winner Kevin has maintained his weight loss and has just completed the London Marathon while Jodie Prenger, who won a previous series, went on to appear as Nancy on the hit BBC Show I'd Do Anything when her weight loss gave her a new-found confidence."
ITV's director of factual, daytime and GMTV Alison Sharman said: "This is a one of the great formats of recent years. It is a wonderfully entertaining watch, with powerful and inspirational stories at its heart. I am delighted that an ITV primetime audience will now be able to enjoy it."
Hopefuls can currently apply to take part in the series on www.biggestloseruk.com.