Speaking at the launch of the second series, Robert Sheehan promised that the episode will have a festive tone.
"It's almost sickly Christmassy," Sheehan, who plays Nathan, joked. "It's overly Christmassy."
The show's creator Howard Overman added: "There's a birth scene the like of which [you've never seen]... I'm not sure it will be popular among Christians."
Lauren Socha, who plays Kelly, explained that the scene is "very weird". Meanwhile, Sheehan compared it to Alien, adding: "It's in a manger."
Misfits returns for its second series on November 11 at 10pm on E4.