The series focuses on a group of community service participants who receive superpowers after a freak storm.
The CEO of Misfits' production company Murray Ferguson has now told Deadline that US networks and cable channels have expressed interest in the format.
However, Ferguson explained that nothing has been decided yet. The show's creator Howard Overman has previously admitted that he has reservations about the idea of a remake.
Two other Channel 4 dramas, Shameless and Skins, have recently been remade for the US and will both premiere this month.