Joseph Gilgun (Rudy), Nathan Stewart-Jarrett (Curtis) and Matthew McNulty (Seth) will be joined by new cast members Karla Crome (Jess) and Nathan McMullen (Finn) in the episodes.
Matt Stokoe (Black Mirror) has also joined the cast as Alex, it has been confirmed. The new regular was previously described as "good-looking" but "standoffish".
Jess and Finn's powers on the E4 drama have also been revealed - the former will have X-ray vision, while the latter will be "telekinetic, but not in an A-list kind of way".
The new Misfits team will face threats including "a six-foot killer rabbit" and the Four Horsemen of the Apocalypse in eight 60-minute episodes.
Series four of Misfits - written by creator Howard Overman and Jon Brown (Fresh Meat) - will air on Channel 4 in late 2012.
> Karla Crome: 'My Misfits character is a tough cookie'
Watch Joseph Gilgun discuss Misfits with Digital Spy below: