The 31-year-old development chef screamed with disbelief after receiving the most votes to win in tonight's final, beating Adam Kelly.
Luke left the house to huge cheers and was presented with the £50,000 prize money by Brian Dowling, as fireworks went off above the Elstree compound.
"It's great to feel acceptance," Luke said of his win. "I don't think it's sunk in yet. A big part of it was about acceptance. All my life I've been an outsider. Thank you so much."
Speaking of the divide in the house, he added; "It was pretty traumatic when it was at its worst. You did feel alone in the house and that's how [Deana, Adam and I] found each other. Without Adam and Deana I would have been alone all the time."
Luke also described Adam as a "genuine and "down-to-earth guy" who made him "feel safe" in the Big Brother house.
On what he's learned about himself, Luke concluded: "I've learned that I can be very stubborn, very determined and quite sarcastic at times."
Luke was joined on stage by wife Becky at the end of the show to celebrate their one-year anniversary.
Deana Uppal finished in third place, with Sara McLean and Luke Scrase coming fourth and fifth respectively.