The actress was ejected from the Elstree compound after fellow nominees Darryn Lyons, Bobby Sabel and Lucien Laviscount received more public votes to save than her.
Brian Dowling began by announcing that Lyons and Laviscount had received the most public votes and were safe from the chop.
Reid seemed relatively unsurprised by the news of her eviction.
Amy Childs and Jedward said: "We love you," as Reid left the house in a subdued manner.
"You're going to see your husband," Kerry Katona told Reid as the housemates said goodbye to her.
She was greeted by a mixture of boos and cheers as she left the house to the sound of Lady GaGa's 'Born This Way'.
Reid was one of the four housemates not chosen to be immune from eviction tonight by Pamela Bach-Hasselhoff, who left the house on Wednesday night.
> Celebrity Big Brother: Latest pictures from the house
Watch the moment Tara Reid was evicted from Celebrity Big Brother below: