The '80s supermodel, who was evicted over the couple - nicknamed Speidi - in the first public vote last week, claimed that her former co-stars "don't backstab" and are "respectful" of other people.
"When they took Heidi and Spencer into the [basement]... they love being alone, they love snuggling up," she told ITV's Daybreak today (January 14).
"They're real, they're spiritual, they don't backstab, they're kind and they didn't kiss because no-one else had a partner and they're being respectful.
"So I can say that they are absolutely genuine, honest people and I can't wait to go and see them in Colorado."
Hamilton even named Speidi as one of her picks to win the show, along with Neil Ruddock and Rylan Clark.
Admitting that she had become "addicted" to Celebrity Big Brother since coming out, Hamilton said of her own stint in the show: "I had the best time in there... 75% of the time I was having a laugh, 25% of the time I was a bit 'miz'. You saw a lot of the 25%."
The 54-year-old previously told Digital Spy that she believes her ex-Celebrity Big Brother housemates "are all playing games".
Heidi and Spencer are facing Rylan, Claire Richards and Lacey Banghard in the next public vote.
> Celebrity Big Brother's Heidi and Spencer - love them or hate them?
Photo gallery - Celebrity Big Brother Day 10: