He may be trying to forget about Food Glorious Food, Red or Black? must still itch him, and X Factor has failed to get anywhere close to dislodging Idol as the No.1 singing contest in the US, but none of these blunders have softened his ruthless streak.
Cowell launches yet another series of Britain's Got Talent on Saturday, April 13 and the big boss is going head-to-head with his latest TV nemesis, BBC One's The Voice.
For 75 minutes the two shows will clash and while plenty of people will watch one live and the other later at their own leisure, the true victor will be the one who secures the most eyeballs live on Saturday night.
The Voice gave Cowell a good fright in 2012, easily beating Got Talent when they overlapped for brief 10, 15 and 20-minute overlaps. However, by the end of the series, Got Talent soared ahead in the live shows, while the BBC series wilted.
Cowell and ITV can sniff blood. Ant & Dec took a big chunk out of The Voice's series premiere audience last weekend and will probably do so again this Saturday. Anyone with a grudge against the BBC, Jessie J or spinning chairs is ready to stick the knife into The Voice UK and Cowell will be only too delighted if he helps deliver the fatal blow.
The Syco boss has always insisted that he hates scheduling battles and "silly games" with the BBC, but ITV's shift of Got Talent to the unusually early time of 7pm is a clear declaration of intent. Cowell was fuming in America last year when the US Voice deliberately placed a show against X Factor USA and beat him. This looks like it could be a slice of revenge.
Obviously, the real losers are TV viewers. Saturday night TV should be about mass entertainment and family fun and The Voice and Got Talent are two of the best shows around right now at delivering that.
We can always tune in later on +1 or iPlayer, but it never feels the same and you can't join in the silliness and hashtagging on Twitter either. Egos and industry rivalry are spoiling things for viewers.
Both shows are created to be watched live as event telly and it's a real shame that we have to pick one. Team Voice or Team Cowell. Who will win? You decide.
What show will you watch on Saturday, April 13? Let us know below!