Matt Lucas, Jimmy Carr, Joan Rivers, Ian Wright and Malcolm McLaren are among the celebrities who will take on the role of Big Brother for the E4 show, which will follow a group of "young and gifted" housemates.
The show's chiefs have promised that the stars will have complete freedom when they each take their turn to hijack the series.
"For instance, they could cause mischief by telling some of the housemates who hates them and has been slagging them off," a show insider told the Daily Star. "They can do pretty much what they like."
Big Brother: Celebrity Hijack launches at 9pm tonight on E4.