Starring Vanessa Williams (Desperate Housewives) and Terry O'Quinn (Lost), the story is based around The Drake, a Park Avenue destination with a strange and dark hold over its tenants.
Watch the ITV2 trailer for 666 Park Avenue:
The show lasts for a complete 13-episode first season, but will not have a second run after getting axed by ABC in America.
However, the show's producers have been tweaking the final episodes, which have yet to air in the US, and have promised that they will answer fans' questions.
"All your questions will be answered," said show exec Matt Miller. "We hope fans of the show continue watching all the way to the end of the incredible journey to the dark side."
666 Park Avenue starts on Tuesday, February 19 at 10pm on ITV2.