The 39-year-old presenter, who hosts Friday night comedy talkshow King of..., admitted that her sexual advances on the Ian Beale actor may have backfired.
"He's my go-to for everything - I rubbed up against him once and he looked appalled," she told Buzz. "I've asked him to come on King Of..., but he won't."
Winkleman, who has been married for 11 years to film producer Kris Thykier, recently described the programme as "the s**ttest thing you'll ever see".
The Film 2011 presenter has previously confessed to a crush on Channel 4 newsreader Jon Snow, stating her belief that "no-one wears a tie as jauntily as him".
Channel 4's King Of... continues tonight at 9.30pm, featuring Jessie Wallace and Stephen Mangan as this week's guests.