The channel is yet to confirm an exact air-date for series two's launch, but it will air ahead of the BBC America premiere on May 10.
Dominic Mitchell's zombie saga will pick up nine months after the devastating events of the first series, with PDS sufferer Kieren (Luke Newberry) desperate to escape his hometown of Roarton.
However, the arrival of two new figures - radical politician Maxine Martin (Wunmi Mosaku) and PDS rights activist Simon (Emmett Scanlan) - threaten to disrupt the town's fragile peace.
The new six-part run will expand on the mythology introduced in the first series, creator Mitchell has hinted.
"With the first series, we had three hours, so it was good to be self-contained," the writer said. "I wanted to explore the mythology more in series two - but it's still domestic and everything is still channelled through Kieren's experience."
The first series - which aired in early 2013 - was recently nominated in this year's BAFTA Craft Awards.
In the Flesh returning to BBC Three: Series 2's secrets revealed
Watch a trailer for In the Flesh below: