The fantasy series is being tipped as a replacement for the popular Merlin, which concluded on Christmas Eve, 2012.
Mark Addy (Game of Thrones), Juliet Stevenson (The Village), Sarah Parish (Monroe) and Jemima Rooper (Lost in Austen) will all star in the series.
The quartet are joined by War Horse actor Robert Emms, Dancing On The Edge star Jack Donnelly and Djinn's Aiysha Hart.
"I am very excited to be invited along on this epic adventure," said Mark Addy. "The scripts bring to life ancient myths with such a vibrancy and sense of humour; I knew I wanted to be a part of it."
Sarah Parish added that she is "thrilled" to be part of such an "exciting project", while Juliet Stevenson described herself as "delighted" with her role and "looking forward to a great adventure".
A 13-part series, Atlantis is set in a time of legendary heroes, mythical creatures and gods, with Greek myths and legends re-imagined for a new generation.
Howard Overman (Misfits) is creator and head writer for the drama, which will be exec produced by Merlin's Johnny Capps and Julian Murphy.
"The fantastic cast announced for Atlantis is testament to the ambition and scale of Howard Overman's scripts," said Ben Stephenson, Controller of BBC Drama Commissioning.
"Some of the UK's best-loved actors are joining our newest talent to take the BBC One audience to a rich and wonderful world where any adventure is possible."
Filming on Atlantis will begin in April in Wales and Morocco, for transmission in the autumn.
> BBC announces new series Atlantis to replace Merlin
> Atlantis casts first lead: Robert Emms joins BBC Merlin replacement