Chris Barrie, Craig Charles, Danny John-Jules and Robert Llewellyn reprise their roles as Rimmer, Lister, the Cat and Kryten respectively in the series, which incorporates some concepts from the aborted movie adaptation.
Digital Spy sat down with Barrie, Charles and Llewellyn to discuss what sets the new series apart from 2009 revival Red Dwarf: Back to Earth.
"We're too old for adventures now," Charles joked of the series, which sees the show return to a more dialogue-focused approach, with episodes taking place chiefly onboard Red Dwarf. "We're far too old to be flying around space saving the universe. Sit at home, feet up, pipe and slippers, bit of conversation."
"It's classic Red Dwarf, as we knew it from series one to eight," Barrie added, "which I guess the fans are really comfortable with. It could well be some of the best shows we've ever made."
Asked what it was that had made the show - which first aired in 1988 - such an enduring success, the cast suggested that both their chemistry and the timeless setting had been crucial.
"The four of us have a peculiar chemistry that's very difficult to recreate. I know they tried to recreate it in America, and it didn't seem to have the chemistry, and maybe it's because of the class system," Charles explained.
"I mean, we're four completely different people, me and Chris are so very, very different. But put us in a room together and we can bounce off each other quite well."
"It's in its own world," Barrie mused, "and shows like that don't really date that much, because it is in its own space world. Fantastic writing and the chemistry, I think, have kept it going."
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Red Dwarf X starts on Dave (Sky 111, Virgin 128, Freeview 12) on Thursday, October 4 at 9pm.
The series is available to download from October and buy on DVD from November 19.
Watch a teaser for the new series below:
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