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Writing on his Twitter page, the comedian posted a photograph of himself with Tennant and revealed that the music quiz lineup will also include Doctor Who actors Catherine Tate and Bernard Cribbins.
The show will also feature Jo Whiley and Jamie Cullum as well as regular panellist Noel Fielding.
Jupitus said: "NMTB Xmas Doctor Who special - Tennant, D. hosts Cullum, J. & Tate, C. with Fielding and Whiley, J. & Cribbins, B. with Jupitus.
"Cribbins sat next to me singing Right Said Fred... Utter joy."
It is rumoured that the episode, which will air on December 16, could also feature the Tardis, Cybermen and the Ood.
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