The first half of the show's sixth run will begin on BBC One on Saturday 23 April, according to Doctor Who Magazine.
The first episode, written by showrunner Steven Moffat, will also air on the same date in the US.
Supernatural actor Mark Sheppard and Jonathan Creek's Stuart Milligan will both appear in the opening two-parter, which is set in '60s America.
Subsequent episodes will include guest spots from Hugh Bonneville, David Walliams and a returning James Corden.
Writers confirmed for the series include Sherlock scribe Steve Thompson, Being Human creator Toby Whithouse and fantasy author Neil Gaiman.
After an initial run of seven episodes, Doctor Who will take a two-month hiatus and return to BBC One in September.