The Farscape star will appear in the sci-fi drama's seventh series, according to Doctor Who Magazine.
The episode - written by Being Human creator Toby Whithouse - is said to be set in the Wild West. Upstairs Downstairs director Saul Metzstein will helm the instalment.
Best known for playing John Crichton on Farscape from 1999 to 2003, Browder later starred in Stargate SG-1 and appeared in a recent episode of Chuck.
Other guest stars confirmed for the next series of Doctor Who include Upstairs Downstairs star Adrian Scarborough, Sherlock's Rupert Graves and Harry Potter's David Bradley.
Mark Williams (The Fast Show) will also appear in a forthcoming episode as a character named Brian Williams.
Doctor Who will return to BBC One in the autumn.
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Watch a clip of Ben Browder on Farscape below: