The actor - who plays Captain Jack Harkness - has previously made clear his desire to be part of the sci-fi drama's celebratory episodes.
"Matt [Smith] and I actually had a conversation at the BBC once, sitting around a table - [we both] thought it would be a great idea," he told MTV Geek. "[Showrunner] Steven [Moffat] thought it would be a great idea.
"This is my opinion - I think it would be a shame if Captain Jack wasn't involved in the 50th anniversary, because he was such a... big presence within the show itself and also within [spinoff series] Torchwood."
Barrowman called on Doctor Who fans to campaign for Jack's return in time for the milestone.
"It's not up to me, it's up to the executives, and it's also kind of up to the fans, because if they want it, all they have to do is... start writing," he suggested. "[The fans] have been known to change things."
Last year, Barrowman told Digital Spy that fans should "send e-mails and write to" the BBC to bring Jack back.
The star recently signed up for ABC drama pilot Gilded Lilys from Grey's Anatomy creator Shonda Rhimes.
> Doctor Who's Steven Moffat: 'The companion is the main character'
Watch the trailer for the next series of Doctor Who below: