The cult comics, TV, games and movies convention will be visited by stars Matt Smith, Arthur Darvill and Karen Gillan and producers Steven Moffat and Caroline Skinner for a panel discussion with fans on Sunday, July 15.
New footage from the show's upcoming series - the last to feature Gillan and Darvill - will also premiere at the event.
Doctor Who will return to BBC One and BBC America in August. The first episode, 'Asylum of the Daleks', will be screened for the first time at BFI Southbank in London on August 14.
Dame Diana Rigg, Rachael Stirling, David Warner (Titanic), Liam Cunningham (Game of Thrones), Jessica Raine (Call the Midwife) and Dougray Scott will all make guest appearances in the new series.
Other new additions to the San Diego Comic-Con event include a Fringe panel to celebrate the sci-fi show's upcoming final season and a Buffy the Vampire Slayer retrospective to salute the franchise's 20th birthday.