Agyeman played The Doctor's companion Martha Jones in Doctor Who's third series, later returning for appearances in series four and in David Tennant's last episodes 'The End of Time'.
The 33-year-old actress has commented in the past that she would relish the chance to honour the history of Doctor Who for the upcoming anniversary.
"If they want to do a big group thing, I can't really envisage anybody in the Who family saying no because it's quite a marked occasion and a good opportunity to rekindle," Agyeman said in late 2011.
Agyeman discussed Doctor Who further in a recent Crave Online interview, disclosing that there will be no return for Martha Jones this year.
"I'm doing two things for the 50th but nothing to do with being in the drama," the star revealed.
She went on to say: "I got misquoted hideously once saying that there are some rumblings going on about being involved in the 50th in terms of the drama. It's not.
"It's in terms of conventions and interviews and things like that, which we're all doing stuff to promote the 50th. We have to. It's the Doctor Who family and we want to."
Little is known about Doctor Who's rumoured 50th anniversary special, other than showrunner Steven Moffat's promise that the show will "take over television".
Tenth Doctor actor David Tennant recently refused to comment on The Jonathan Ross Show about rumours that he will appear in a multi-Doctor special.
It has been announced that classic Doctor Who stars Tom Baker, Peter Davison, Colin Baker, Sylvester McCoy and Paul McGann will all record a Big Finish multi-Doctor audio drama in celebration of the anniversary.
Watch a trailer for Doctor Who's upcoming episodes below: