O'Mara played the glamorous villainess in two 1980s Doctor Who adventures, and told Digital Spy that she would love to play the part again.
"I would love to come back," said the actress, who was promoting her upcoming event An Evening with Kate O'Mara, where she will look back on her career.
"I have white hair now, but a lot of it, and I'm still very glamorous and so I won't disappoint, I hope! I'll still be wearing the tight leather trousers and high-heel boots, regardless of what age! That's what the fans are expecting, so that's what you've got to give them."
74-year-old O'Mara also claimed that older viewers can't "engage with" or "identify with" a lot of today's youth-oriented programming.
"I'm a much older woman and there's a huge population of older people who, if they're watching television, they can't watch Hollyoaks.
"If you put a much older woman in Doctor Who, they can identify with it. I think it's quite an interesting concept and if you remember things like Grimm's Fairytales, the older woman is often the villainess, often the terrifying figure - why I do not know, but often she is. I think it's an idea to be exploited."
An Evening with Kate O'Mara takes place on Saturday, October 19 at 7pm at The Misty Moon Gallery, Ladywell Tavern, 80 Ladywell Road, SE13 7HS.
Kate will also attend the Doctor Who 50th Anniversary celebration at London's Excel in November.
> Doctor Who 50th anniversary episode for simulcast worldwide broadcast
Watch a clip of Kate O'Mara in classic Doctor Who below: