Auditions for series five and six will be held in London and Bristol in April.
Head of Channel 4 drama Camilla Campbell commented: "Skins has always been about new talent, both on and off screen, and the decision to recast the series every two years is one of the reasons Skins stands out as a truly distinctive show.
"It’s a testament to the talent and commitment of [creator] Bryan Elsley and his team that they are able to pull this off. Now another group of teenagers will have the rare opportunity to be part of a British drama series that says something about their lives and is one of the most exciting shows on television. I can’t wait to find out who they will be."
As previously reported, the entire current cast - including Kaya Scodelario and Luke Pasqualino - will leave the show when series four concludes next Thursday.
Series five, made by Company Pictures and Stormdog Films, will be made up of eight episodes.
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