The E4 teen drama has been recommissioned for a special seventh run - made up of three films broken up into six parts - to be broadcast in 2013, Digital Spy can confirm.
Famous Skins characters from the past five years will appear in the 'celebratory' series.
Nicholas Hoult (Tony), Kaya Scodelario (Effy), Jack O'Connell (Cook) and Luke Pasqualino (Freddie) are among those who could return.
> Poll: Which former Skins characters should come back?
"Channel 4 today confirmed that next year's series of E4's teen drama Skins will be its last," the broadcaster said this evening.
"The new series will be a celebration of this truly iconic series, and will go to air in early 2013."
"Skins is a brilliant show which has defined a generation and will go down as a game-changing piece of television," the statement added.
"But after seven series it is time for E4 to make way for the next generation of the bold, the new and the innovative."
Skins, which launched in 2007, is currently airing its sixth series every Monday at 10pm on E4.