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The actor, who has played paramedic-turned-intern Tony Gates since 2006, said he did not want the commitment of his own show.
NBC and Warner Brothers are believed to have approached him to ascertain his feelings about a new project.
An insider told the New York Daily News: "Stamos wasn't having it. He's not interested in being locked into a contract right now. He's got other options open."
It was recently confirmed that the medical drama is to return for a 15th season before bowing out next February.
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