The series - based on the novel by Michael Dobbs and adapted by Beau Willimon (The Ides of March) - stars Hollywood icon Kevin Spacey as Francis 'Frank' Underwood, a morally ambiguous politician with a ruthless ambition.
Kate Mara (127 Hours, American Horror Story) also appears as Zoe Barnes - a determined Washington reporter who makes a deal with Underwood that lands her a massive scoop, but might also end up costing her her soul...
[Above: The cast and crew of 'House of Cards' at the show's London premiere]
Kate, can you give us any hints about Zoe's journey across the 13 episodes?
"I don't want to, because that might make it less interesting for you! But I can say that her journey with Francis certainly becomes more and more interesting.
"The more she becomes involved in his world, the more dangerous it becomes, and their relationship just grows and becomes more intense throughout the series, which is really fun to play."
Did you do any research into journalism for the part?
"No - everyone asks that question and now I sort of think, 'Should I have done that?', but there was so much there for me in Beau's first two scripts.
"And the fact that Zoe was a journalist... it was important, but it wasn't the main thing about her that I felt I needed to connect to - she really could be doing any job.
"I think her strongest characteristic is that she has incredible drive and passion for her job. One of the things I related to about Zoe was her ambition - I've been acting since I was a kid and, as a 12-year-old, I was so determined.
"I've become a lot more calm and chill now that I've been doing it for so long, but that was the thing about her that I really respected. Of course, there are things about her - her morals and things - that I didn't necessarily relate to, but that just made it fun."
House of Cards delves into the dark side of politics - do you have any interest in that world?
"I don't follow politics at all, but one of the great things about House of Cards is that you don't have to be be interested in that world in order to enjoy watching it.
"When I was reading the scripts, I really couldn't put it down, I couldn't wait to see what was going to happen next with these people, because it was also very much about the power struggle between human beings and different relationships, which I find fascinating."
[Above: Kevin Spacey and Robin Wright in 'House of Cards']
Why do you think Zoe is so drawn to Francis Underwood?
"I think Zoe's attracted to powerful people because she wants to be powerful herself. I think she sees some of herself in him, and he probably sees a little bit of his former self in her - just in how gutsy she is.
"They definitely use each other and she knows when she's being manipulated, but she lets it happen because she knows she can use it to her advantage."
And why do you think the audience will be drawn to Francis?
"We love watching a train wreck! It's kind of fun to watch people play out things that we wouldn't have the guts to do in our real lives. Also, Kevin Spacey is just so good at being bad - it's hard not to love him, no matter how evil he is!"
How was the experience of working with David Fincher on this project?
"Amazing. He's everything I heard he was from my friends who've worked with him, and my sister [The Girl with the Dragon Tattoo star Rooney Mara] who's worked with him, and he's as intense as people say he is, in all the great ways.
"I've never felt so challenged and so exhausted, and yet fulfilled, going home from work every night. You never stop thinking when you're working with him.
"The hardest thing about acting is the downtime and the waiting inbetween takes, but with David, there's this crazy speed and it's sort of non-stop. You don't have time to go sit in your trailer and watch episodes of Friends inbetween takes, which you do with a lot of directors. But he constantly has you thinking and working - for me, that's exactly what I want."
Watch the trailer for House of Cards below:
What was the most challenging part of working on House of Cards?
"Just the challenge of working with people who are on a certain level - like Kevin Spacey and Robin Wright and David. I respect them all so much, so I didn't want to just show up and figure it out on set as I went along. I wanted to take as much from it as I possibly could.
"I don't know that there was a most challenging part, but it was all challenging in the best, most fulfilling way. It was definitely the most challenging experience I've had thus far in my career."
Are you excited to star in a series that could run for multiple seasons?
"I can't really say because I know Zoe's story - I know exactly how much I'm doing, but it would ruin it for you guys!"
Did shooting this feel like working in TV or like making an epic movie?
"It didn't feel like TV at all. Probably because of the people involved, it felt like we did six movies in a row and it was with the people that I want to be making movies with.
"It was the best of both worlds. You get tons of time, you get 13 hours to work with these people and to create these characters, and yet it feels like a movie and it looks like a movie, and all of the great things that go along with that."
What do you think of people being able to watch all 13 episodes at once?
"I barely ever watch live TV any more. I typically wait until I have a few episodes on TiVo or whatever, to watch them in a row. So I think it's a smart idea and I'm surprised it's only happening now - I think it's what most people would want. You can manage your time the way you want it.
"Hopefully people just can't stop watching it and pull an all-nighter! It'll be interesting to see what people think of it."
House of Cards will be available to watch in full exclusively on Netflix from Friday, February 1.