The actor, who recently signed up for a multi-episode arc in Heroes, will play an artist suffering from unexplained outbursts of rage.
A statement from a House publicist shed more light on the character: "Breckin guest stars on the show in the coming season as a struggling artist - a painter whose undiagnosed illness distorts his work and his perception, and threatens to undermine his career, his relationship, everything in his life."
Speaking to E! Online about his role, Meyer said: "They can't figure out what's wrong with me. A lot of things go wrong. I blow up like a balloon at one point. I get violent [with] a lady. I get inappropriate."
Meyer will appear in the third episode of the upcoming fifth season of House, which begins Tuesday, September 16 in the US.