The network granted a 13-episode season order in April, but has decided not to extend the show past its 13th season, says The Hollywood Reporter.
Premiering in 1997, King Of The Hill revolves around propane salesman Hank Hill and his Texan family.
Creators Greg Daniels and Mike Judge have moved on to new projects. Daniels oversees the US version of The Office, while Judge has directed the films Office Space and Idiocracy.
Judge continued to feature in the voice cast, which also includes Kathy Najimy, Pamela Adlon, Brittany Murphy and Tom Petty.