The former Baywatch star will portray the character of Vanessa, the wife of Dr Michael Mancini (Thomas Calabro) and mother of his youngest son Noah, on the remake, E! reports.
The 31-year-old, who was once engaged to actor Bruce Willis, joins recent cast additions Taryn Manning and Taylor Cole for a multi-arc storyline.
Original series alumni Daphne Zuniga and Josie Bissett will guest star on the revamped TV show.
Melrose Place first aired on the Fox network for seven seasons between 1992 and 1999, while the new format will debut in the US on September 8 on The CW.