Rex Features
The wife of US President Barack is expected to appear via satellite from Washington, DC and will answer ten quick questions from the NBC show's host.
Previous participants in Leno's routine have included Senator John McCain and basketball star LeBron James.
The first lady previously appeared on the presenter's Tonight Show last year, just before the US election.
During her live appearance, Leno teased her about how much her outfit must have cost, but she surprised the audience by telling them it was from J Crew - a mid-market chain store.
